Welcome to the Holiday Inn Express Hannibal Hotel located near Highway 61 in America's Hometown, Hannibal, Missouri. We feature 74 rooms, including 16 kitchenette suites, and 4 Jacuzzi Suites. The Holiday Inn Express also offers a heated indoor swimming pool, hot tub, fitness center, laundry facility, business center, free high-speed internet in all rooms, meeting room, and free extended continental breakfast. We also offer the in room amenities as follows, hair dryers, iron with a full size board, coffee pots in every room, and free HBO and Cinemax. There are many restaurants, and shopping areas located near the Holiday Inn Express. We are also only located about 3 miles from the historic downtown area. The downtown area includes the Mark Twain Home, Museum, and other Mark Twain attractions. Hannibal also has a spot the kids would enjoy called Sawyer’s Creek, which is located right across the street from the Mark Twain Cave, and Cameron Cave. Our friendly staff is here 24 hours a day to welcome you to Mark Twain's Hometown, and to our hotel the Holiday Inn Express, Hannibal.