The Holiday Inn Express Sikeston Hotel is located at Mile Marker 67, off Interstate 55. Our hotel features free local phone calls, complimentary continental breakfast, outdoor pool, exercise room, cable and HBO. Enjoy a unique breakfast experience at our new Express Start Breakfast Bar served every morning featuring a selection of fruits, juices, cereals, breads/pastries, and even hardboiled eggs. We have also created the world's best tasting cinnamon roll. Visit Sikeston and stay smart at the Holiday Inn Express Hotel.